An Efficient Synthesis of Acenaphtho[1,2- b]indole Derivatives via Domino Reaction

Molecules. 2018 Nov 21;23(11):3045. doi: 10.3390/molecules23113045.

Abstract

A concise and efficient synthesis of acenaphtho[1,2-b]indole derivatives via the domino reactions of enaminones with acenaphthoquinone catalyzed by l-proline has been developed. This protocol has the advantages of good yields, operational convenience and high regioselectivity.

Keywords: acenaphtho[1,2-b]indole; acenaphthoquinone; domino reaction; enaminone; l-proline.

MeSH terms

  • Acenaphthenes / chemical synthesis*
  • Acenaphthenes / chemistry
  • Catalysis
  • Cyclization
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Molecular Structure
  • Naphthoquinones / chemistry
  • Proline / chemistry

Substances

  • Acenaphthenes
  • Indoles
  • Naphthoquinones
  • Proline