Development of New Analgesics: An Answer to Opioid Epidemic

Tony L Yaksh; Matthew A Hunt; Gilson G Dos Santos

doi:10.1016/j.tips.2018.10.003

Development of New Analgesics: An Answer to Opioid Epidemic

Trends Pharmacol Sci. 2018 Dec;39(12):1000-1002. doi: 10.1016/j.tips.2018.10.003.

Authors

Tony L Yaksh¹, Matthew A Hunt², Gilson G Dos Santos²

Affiliations

¹ Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA. Electronic address: tyaksh@ucsd.edu.
² Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.

PMID: 30454767
DOI: 10.1016/j.tips.2018.10.003

Abstract

Management of pain is a fundamental imperative in medicine. Current analgesics suffer from limitations related to efficacy and adverse events of which abuse potential has assumed an important role. Here we highlight the factors that drive the development of novel analgesics and the advances made in the field.

Keywords: analgesics; dependence; drug abuse; tolerance.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Analgesics, Opioid / adverse effects*
Analgesics, Opioid / chemical synthesis
Analgesics, Opioid / therapeutic use
Drug Discovery*
Epidemics / prevention & control*
Humans
Opioid-Related Disorders / drug therapy*
Opioid-Related Disorders / epidemiology
Opioid-Related Disorders / etiology

Substances

Analgesics, Opioid

Abstract

Publication types

MeSH terms

Substances

Grants and funding