Histologic similarities in children with eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia

Nathalie Nguyen; Anna Baumgarten; Benjamin L Wright; Kelley E Capocelli; Zhaoxing Pan; James J Lee; Glenn T Furuta; Joanne C Masterson

doi:10.1016/j.jaci.2018.10.047

Histologic similarities in children with eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia

J Allergy Clin Immunol. 2019 Mar;143(3):1237-1240.e2. doi: 10.1016/j.jaci.2018.10.047. Epub 2018 Nov 14.

Authors

Nathalie Nguyen¹, Anna Baumgarten², Benjamin L Wright³, Kelley E Capocelli⁴, Zhaoxing Pan⁵, James J Lee⁶, Glenn T Furuta⁷, Joanne C Masterson⁸

Affiliations

¹ Section of Pediatric Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colo; Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colo. Electronic address: Nathalie.Nguyen@childrenscolorado.org.
² Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colo.
³ Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic in Arizona, Scottsdale, Ariz; Division of Pulmonology, Phoenix Children's Hospital, Phoenix, Ariz.
⁴ Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colo; Department of Pathology, Children's Hospital Colorado, Aurora, Colo.
⁵ Research Institute, Children's Hospital Colorado, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colo.
⁶ Division of Allergy, Asthma and Clinical Immunology, Mayo Clinic in Arizona, Scottsdale, Ariz.
⁷ Section of Pediatric Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colo; Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colo.
⁸ Section of Pediatric Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colo; Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colo; Institute of Immunology, Department of Biology, Maynooth University, Maynooth, Ireland.

Abstract

The EPX histologic scoring system can be used to differentiate children with EoE and PPI-REE relative to GERD, supporting the relationship between these 2 groups and enhancing current diagnostic and treatment approaches.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Child, Preschool
Eosinophil Peroxidase / immunology*
Eosinophilia / diagnosis*
Eosinophilia / drug therapy
Eosinophilia / enzymology
Eosinophilia / immunology
Esophagitis / diagnosis*
Esophagitis / enzymology
Esophagitis / immunology
Esophagus / enzymology
Esophagus / immunology
Female
Gastroesophageal Reflux / diagnosis*
Gastroesophageal Reflux / enzymology
Gastroesophageal Reflux / immunology
Humans
Infant
Leukocyte Count
Male
Proton Pump Inhibitors / therapeutic use

Substances

Proton Pump Inhibitors
Eosinophil Peroxidase

Abstract

Publication types

MeSH terms

Substances

Grants and funding