Evidence for increased completed suicide in first-degree relatives of LRRK2 G2019S mutation Parkinson's disease

Roberto Angel Ortega; Mark Groves; Anat Mirelman; Roy N Alcalay; Deborah Raymond; Sonya Elango; Helen Mejia-Santana; Nir Giladi; Karen Marder; Susan B Bressman; Rachel Saunders-Pullman

doi:10.1136/jnnp-2018-319364

Evidence for increased completed suicide in first-degree relatives of LRRK2 G2019S mutation Parkinson's disease

J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):843-844. doi: 10.1136/jnnp-2018-319364. Epub 2018 Nov 8.

Authors

Roberto Angel Ortega^{1

2}, Mark Groves^{3

2}, Anat Mirelman^{4

5

6

7}, Roy N Alcalay⁸, Deborah Raymond^{3

2}, Sonya Elango^{3

2}, Helen Mejia-Santana⁸, Nir Giladi^{4

6

7}, Karen Marder^{8

9}, Susan B Bressman^{3

2}, Rachel Saunders-Pullman^{3

2}

Affiliations

¹ Department of Neurology, Mount Sinai Beth Israel Medical Center, New York City, New York, USA Roberto.Ortega@mountsinai.org.
² Department of Neurology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
³ Department of Neurology, Mount Sinai Beth Israel Medical Center, New York City, New York, USA.
⁴ Center for the Study of Movement, Cognition, and Mobility, Neurological Institute, Tel Aviv Medical Center, Tel Aviv, Israel.
⁵ Laboratory of Early Markers of Neurodegeneration, Tel Aviv Medical Center, Tel Aviv, Israel.
⁶ Department of Neurology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
⁷ Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
⁸ Department of Neurology, Columbia University Irving Medical Center, New York City, New York, USA.
⁹ Taub Institute for Alzheimer's Disease and the Aging Brain, Columbia University, New York City, New York, USA.

No abstract available

Keywords: Parkinson's disease; genetics; movement disorders; neurogenetics.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Child of Impaired Parents / statistics & numerical data
Female
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / genetics*
Male
Middle Aged
Mutation
Parents
Parkinson Disease / genetics*
Parkinson Disease / psychology
Risk Factors
Siblings
Suicide, Completed / statistics & numerical data*
Young Adult

Substances

LRRK2 protein, human
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Publication types

MeSH terms

Substances

Grants and funding