B Cell Regulation in Autoimmune Diseases

A V Sokolov; A A Shmidt; Y A Lomakin

B Cell Regulation in Autoimmune Diseases

Acta Naturae. 2018 Jul-Sep;10(3):11-22.

Authors

A V Sokolov¹, A A Shmidt¹, Y A Lomakin^{1

2}

Affiliations

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maklaya Str., 16/10, Moscow, 117997, Russia.
² Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskay Str., 18, Kazan, 420008, Russia.

PMID: 30397522
PMCID: PMC6209408

Abstract

Antibody-independent B cell effector functions play an important role in the development and suppression of the immune response. An extensive body of data on cytokine regulation of the immune response by B lymphocytes has been accumulated over the past fifteen years. In this review, we focused on the mechanisms of inflammatory response suppression by subpopulations of regulatory B cells in health and autoimmune pathologies.

Keywords: Breg, regulatory B cells; CD19+CD24(hi)CD38(hi); IL-10; IL-35; Multiple sclerosis; experimental autoimmune encephalomyelitis; rheumatoid arthritis; systemic lupus erythematosus.