Physical control of tissue morphogenesis across scales

Georgina A Stooke-Vaughan; Otger Campàs

doi:10.1016/j.gde.2018.09.002

Physical control of tissue morphogenesis across scales

Curr Opin Genet Dev. 2018 Aug:51:111-119. doi: 10.1016/j.gde.2018.09.002. Epub 2018 Nov 1.

Authors

Georgina A Stooke-Vaughan¹, Otger Campàs²

Affiliations

¹ Department of Mechanical Engineering, University of California, Santa Barbara, California, United States.
² Department of Mechanical Engineering, University of California, Santa Barbara, California, United States; California NanoSystems Institute, University of California, Santa Barbara, California, United States; Department of Molecular, Cell and Developmental Biology, University of California, Santa Barbara, California, United States; Center for Bioengineering, University of California, Santa Barbara, United States. Electronic address: campas@ucsb.edu.

Abstract

During embryogenesis, tissues and organs are progressively shaped into their functional morphologies. While the information about tissue and organ shape is encoded genetically, the sculpting of embryonic structures in the 3D space is ultimately a physical process. The control of physical quantities involved in tissue morphogenesis originates at cellular and subcellular scales, but it is their emergent behavior at supracellular scales that guides morphogenetic events. In this review, we highlight the physical quantities that can be spatiotemporally tuned at supracellular scales to sculpt tissues and organs during embryonic development of animal species, and connect them to the cellular and molecular mechanisms controlling them.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Embryonic Development / genetics*
Epithelium / growth & development
Models, Biological
Morphogenesis / genetics*
Physical Phenomena*

Abstract

Publication types

MeSH terms

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