Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1

Yanhua Zhao; Xiying Yuan; Xiang Li; Yi Zhang

doi:10.1002/jcb.27335

Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1

J Cell Biochem. 2019 Feb;120(2):1527-1531. doi: 10.1002/jcb.27335. Epub 2018 Oct 22.

Authors

Yanhua Zhao¹, Xiying Yuan¹, Xiang Li², Yi Zhang¹

Affiliations

¹ Department of Obstetrics and Gynecology, Xiangya Hospital of Central South University, Changsha, Hunan, China.
² Department of Pathology, Xiangya Hospital of Central South University, Changsha, Hunan, China.

PMID: 30350320
DOI: 10.1002/jcb.27335

Abstract

Cervical cancer (CC) is one of the most common female malignancies, and resveratrol is a polyphenol isolated from the skins of grapes, which has been reported to significantly alter the cellular physiology of tumor cells. However, little is known about the role of phospholipid scramblase 1 (PLSCR1) in pathogenesis of CC. Here, we demonstrated that resveratrol could significantly inhibit both the growth of HeLa cells and expression of PLSCR1. These results suggest that resveratrol-mediated cell growth inhibition can be regulated by PLSCR1.

Keywords: cervical cancer; phospholipid scramblase 1 (PLSCR1); resveratrol.