Effect of recombinant human interferon gamma against human cytomegalovirus

Arch Virol. 1987;94(3-4):323-9. doi: 10.1007/BF01310726.

Abstract

Escherichia coli-derived human interferon-gamma (rIFN-gamma) inhibited the replication of human cytomegalovirus (HCMV) synergistically when combined with IFN-alpha. The induction of HCMV DNA polymerase was inhibited in rIFN-gamma-treated cells. It is suggested that the induction of 2-5 A synthetase does not play an important role in the anti-HCMV actions of IFNs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',5'-Oligoadenylate Synthetase / biosynthesis
  • Cytomegalovirus / enzymology
  • Cytomegalovirus / physiology*
  • DNA-Directed DNA Polymerase / biosynthesis
  • Enzyme Induction
  • Humans
  • Interferon Type I / pharmacology
  • Interferon-gamma / pharmacology*
  • Recombinant Proteins / pharmacology
  • Viral Plaque Assay
  • Viral Proteins / biosynthesis
  • Virus Replication

Substances

  • Interferon Type I
  • Recombinant Proteins
  • Viral Proteins
  • Interferon-gamma
  • DNA-Directed DNA Polymerase
  • 2',5'-Oligoadenylate Synthetase