Abstract
Escherichia coli-derived human interferon-gamma (rIFN-gamma) inhibited the replication of human cytomegalovirus (HCMV) synergistically when combined with IFN-alpha. The induction of HCMV DNA polymerase was inhibited in rIFN-gamma-treated cells. It is suggested that the induction of 2-5 A synthetase does not play an important role in the anti-HCMV actions of IFNs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2',5'-Oligoadenylate Synthetase / biosynthesis
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Cytomegalovirus / enzymology
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Cytomegalovirus / physiology*
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DNA-Directed DNA Polymerase / biosynthesis
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Enzyme Induction
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Humans
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Interferon Type I / pharmacology
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Interferon-gamma / pharmacology*
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Recombinant Proteins / pharmacology
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Viral Plaque Assay
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Viral Proteins / biosynthesis
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Virus Replication
Substances
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Interferon Type I
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Recombinant Proteins
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Viral Proteins
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Interferon-gamma
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DNA-Directed DNA Polymerase
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2',5'-Oligoadenylate Synthetase