Getting a Genomic View of DNA Replication Stress

Lee Zou; Hai Dang Nguyen

doi:10.1016/j.molcel.2018.10.001

Getting a Genomic View of DNA Replication Stress

Mol Cell. 2018 Oct 18;72(2):201-203. doi: 10.1016/j.molcel.2018.10.001.

Authors

Lee Zou¹, Hai Dang Nguyen²

Affiliations

¹ Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115. Electronic address: zou.lee@mgh.harvard.edu.
² Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

PMID: 30340018
DOI: 10.1016/j.molcel.2018.10.001

Abstract

DNA replication forks collapse at numerous sites throughout the genome under replication stress. Studies by Shastri et al. (2018) and Tubbs et al. (2018) used different genomics approaches to map the sites of replication fork collapse, revealing the contribution of specific DNA sequences to replication stress.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

DNA
DNA Damage*
DNA Replication*
Genomics

Substances

DNA

Grants and funding

T32 DK007540/DK/NIDDK NIH HHS/United States