Using double pulsed-field gradient MRI to study tissue microstructure in traumatic brain injury (TBI)

Michal E Komlosh; Dan Benjamini; Elizabeth B Hutchinson; Sarah King; Margalit Haber; Alexandru V Avram; Lynne A Holtzclaw; Abhishek Desai; Carlo Pierpaoli; Peter J Basser

doi:10.1016/j.micromeso.2017.05.030

Using double pulsed-field gradient MRI to study tissue microstructure in traumatic brain injury (TBI)

Microporous Mesoporous Mater. 2018 Oct:269:156-159. doi: 10.1016/j.micromeso.2017.05.030. Epub 2017 Mar 25.

Authors

Michal E Komlosh^{1

2}, Dan Benjamini¹, Elizabeth B Hutchinson^{1

2}, Sarah King^{1

2}, Margalit Haber³, Alexandru V Avram¹, Lynne A Holtzclaw⁴, Abhishek Desai⁵, Carlo Pierpaoli¹, Peter J Basser¹

Affiliations

¹ Section on Quantitative Imaging and Tissue Sciences, NICHD, National Institutes of Health, Bethesda, MD, USA.
² Center for Neuroscience and Regenerative Medicine, Uniform Service University of the Health Sciences, Bethesda, MD, USA.
³ Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
⁴ Microscopy and Imaging Core, NICHD, National Institutes of Health, Bethesda, MD, USA.
⁵ Laboratory of Molecular Signaling, NIAAA, National Institutes of Health, Rockville, MD, USA.

Abstract

Double pulsed-field gradient (dPFG) MRI is proposed as a new sensitive tool to detect and characterize tissue microstructure following diffuse axonal injury. In this study dPFG MRI was used to estimate apparent mean axon diameter in a diffuse axonal injury animal model and in healthy fixed mouse brain. Histological analysis was used to verify the presence of the injury detected by MRI.

Keywords: CHIMERA; DAI; DDE; DTI; MRI; TBI; anisotropic diffusion; d-PFG; diffusion; microstructure.

Abstract

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