A unified deep-learning network to accurately segment insulin granules of different animal models imaged under different electron microscopy methodologies

Affiliations

• ¹ State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, 100871, China.
• ² Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
• ³ University of Chinese Academy of Sciences, Beijing, 100049, China.
• ⁴ Marine Science College of Zhejiang Ocean University, National Engineering Research Center of Marine Facilities Aquaculture, Zhoushan, 316022, China.
• ⁵ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
• ⁶ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. xueyanhong@ibp.ac.cn.
• ⁷ University of Chinese Academy of Sciences, Beijing, 100049, China. yaoerlin@ict.ac.cn.