T cells take aim at a ubiquitous autoantigen in multiple sclerosis

Sci Transl Med. 2018 Oct 10;10(462):eaau8826. doi: 10.1126/scitranslmed.aau8826.

Authors

Joseph J Sabatino Jr¹, Scott S Zamvil²

Affiliations

¹ Multiple Sclerosis Center, Department of Neurology and Program in Immunology, University of California, San Francisco, San Francisco, CA 94107, USA.
² Multiple Sclerosis Center, Department of Neurology and Program in Immunology, University of California, San Francisco, San Francisco, CA 94107, USA. zamvil@ucsf.neuroimmunol.org.

PMID: 30305455
DOI: 10.1126/scitranslmed.aau8826

Abstract

CD4⁺ T cells from multiple sclerosis lesions target a ubiquitous self-antigen that is shared by gut commensal bacteria (Planas et al, this issue).

Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Autoantigens / immunology*
Fucose / metabolism
Glycosyltransferases / metabolism
Humans
Models, Biological
Multiple Sclerosis / immunology*
T-Lymphocytes / immunology*

Substances

Autoantigens
Fucose
Glycosyltransferases