Objective: To evaluate the clinical features, treatments and prognoses of malignant salivary gland tumors of the larynx. Methods: A total of 14 patients with malignant salivary gland tumors of the larynx diagnosed and treated in our hospital between 2003 and 2014 were analyzed retrospectively, and were compared with 62 patients from the Surveillance, Epidemiology, and End Results: (SEER) database of American for survival rates. Results Among 14 patients from our hospital, 9 males and 5 females, with a median of 66.5 years old; 8 patients with adenoid cystic carcinoma, 4 with mucoepidermoid carcinoma and 2 with adenocarcinoma; supraglottic, glottic and 4 subglottic malignancies respectively accounting for 5, 5 and 4 cases; 8 cases treated with surgery, 5 with surgery and postoperative radiotherapy and/or chemotherapy, and 1 with radiotherapy alone. The 14 patients showed a three-year overall survival rate of 50.0% and a five-year overall survival rate of 42.9%, respectively in contrast with the rates of 67.1% and 59.8% in SEER database. Conclusions: The malignant salivary gland tumor of the larynx is rare and it is difficult to be diagnosed early. It is more likely to occour local recurrence and distant metastasis. Extensive surgical resection with postoperative radiotherapy is advocated.
目的： 探讨喉恶性涎腺肿瘤的临床特点、治疗及预后。 方法： 回顾性分析2003年1月至2014年12月于复旦大学附属眼耳鼻喉科医院耳鼻咽喉科就诊且病理确诊为喉恶性涎腺肿瘤的14例患者的临床资料，并结合美国Surveillance, Epidemiology, and End Results(SEER)数据库对相关病例进行分析。 结果： 14例喉恶性涎腺肿瘤患者中，腺样囊性癌8例，黏液表皮样癌4例，腺癌2例；男9例，女5例，中位年龄66.5岁；声门上区、声门区和声门下区分别为5、5和4例；8例行单纯手术治疗，5例行手术＋术后放/化疗，1例行单纯放疗；3年、5年总体生存率分别为50.0%，42.9%。同期SEER数据库共有喉恶性涎腺肿瘤62例，3年、5年总体生存率分别为67.1%、59.8%。 结论： 喉恶性涎腺肿瘤临床少见，呈黏膜下浸润生长，早期诊断困难，易局部复发和远处转移，手术扩大切除联合术后放疗为主要治疗方法。.
Keywords: Immunohistochemistry; Laryngeal neoplasms; Prognosis; Salivary gland neoplasms; Treatment.