Abstract
Admixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Analgesics, Opioid / chemistry*
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Anesthetics, Combined / chemistry*
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Anesthetics, Dissociative / chemistry*
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Anesthetics, Intravenous / chemistry*
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Chromatography, High Pressure Liquid
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Drug Combinations
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Drug Stability
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Fentanyl / chemistry*
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Ketamine / chemistry*
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Mass Spectrometry
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Propofol / chemistry*
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Remifentanil / chemistry*
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Temperature
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Time Factors
Substances
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Analgesics, Opioid
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Anesthetics, Combined
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Anesthetics, Dissociative
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Anesthetics, Intravenous
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Drug Combinations
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Ketamine
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Remifentanil
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Fentanyl
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Propofol