Nephrotoxicity of Select Rheumatologic Drugs

Rheum Dis Clin North Am. 2018 Nov;44(4):605-617. doi: 10.1016/j.rdc.2018.06.005. Epub 2018 Sep 7.

Abstract

Several drugs commonly used in the management of rheumatic diseases may lead to nephrotoxicity, electrolyte disturbances, and hypertension. Here the authors focus on nonsteroidal antiinflammatory drugs, uric-acid-lowering therapy, and commonly used immunosuppressant therapies. The authors include a drug dosing table for patients with kidney disease.

Keywords: Drug dosing in chronic kidney disease; Drug dosing in hemodialysis; Drug-induced electrolyte disorders; Drug-induced nephrotoxicity.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / adverse effects*
  • Anti-Inflammatory Agents / therapeutic use
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Kidney Diseases / chemically induced*
  • Kidney* / drug effects
  • Kidney* / physiopathology
  • Medication Therapy Management
  • Rheumatic Diseases / drug therapy*

Substances

  • Anti-Inflammatory Agents
  • Immunosuppressive Agents