[Cerebral embolism in Duchenne muscular dystrophy after respiratory tract infection - Report of two cases]

Rinsho Shinkeigaku. 2018 Oct 24;58(10):642-645. doi: 10.5692/clinicalneurol.cn-001135. Epub 2018 Sep 29.
[Article in Japanese]

Abstract

We report cerebral embolism in 2 patients with Duchenne muscular dystrophy (DMD) after respiratory tract infection. A 31-year-old man (Case 1) was admitted to the hospital because of an upper respiratory tract infection, then suddenly developed left-sided hemiparesis. Transthoracic echocardiography revealed an intracardiac thrombus in the left ventricle, and, under assumption of cardioembolic stroke, oral anticoagulation was initiated. Case 2 was a 36-year-old man who developed dysphasia after increasing sputum. Based on brain CT scan findings, we confirmed a diagnosis of cerebral infarction. There was no recurrence in either case. Both cases developed cerebral infarction due to embolism after mild upper respiratory tract infections. DMD patients have various risk factors for thrombus and embolus, while physicians should also be aware of possible cerebral infarction and other coagulation disorders irrespective of respiratory and cardiac therapy.

Keywords: Duchenne muscular dystrophy; coagulation abnormality; intracardiac thrombus; stroke.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticoagulants / administration & dosage
  • Aspirin / administration & dosage
  • Brain / diagnostic imaging
  • Diffusion Magnetic Resonance Imaging
  • Echocardiography
  • Heart Diseases / complications*
  • Heart Diseases / diagnostic imaging
  • Heart Ventricles
  • Heparin / administration & dosage
  • Humans
  • Intracranial Embolism / diagnostic imaging
  • Intracranial Embolism / drug therapy
  • Intracranial Embolism / etiology*
  • Magnetic Resonance Angiography
  • Male
  • Muscular Dystrophy, Duchenne / complications*
  • Respiratory Tract Infections / complications*
  • Risk
  • Thrombosis / complications*
  • Thrombosis / diagnostic imaging
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Warfarin / administration & dosage

Substances

  • Anticoagulants
  • Warfarin
  • Heparin
  • Aspirin