Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers?

Neuropathol Appl Neurobiol. 2019 Feb;45(2):187-189. doi: 10.1111/nan.12517. Epub 2018 Oct 24.

R Guerreiro^{1

2

3}, T Orme², A C Naj^{4

5

6}, A B Kuzma^{5

6}, G D Schellenberg^{5

7}, J Bras^{1

2

3}

¹ UK Dementia Research Institute at UCL (UK DRI), London, UK.
² Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.
³ Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal.
⁴ Department of Biostatistics, Epidemiology, and Informatics/Centre for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
⁵ Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
⁶ Penn Neurodegeneration Genomics Centre, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
⁷ Department of Genetics, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

No abstract available

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