Sensing of chemical warfare agents is today an important target, mainly due to the international scenario. Here a new approach, based on supramolecular multi-topic recognition of dimethyl methylphosphonate, a simulant of chemical warfare agents, is reported. These receptors, based on metal-salen complexes, combine their abilities to establish Lewis acid-base interactions and hydrogen bonds and pave the way for the realization of a new class of supramolecular sensors for the non-covalent recognition of chemical warfare agent simulants.