Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Indrajit Bandyopadhyay; Sandipan Roy Chowdhury; Nishant P Visavadiya; Sidney M Hecht; Omar M Khdour

doi:10.1016/j.dib.2018.08.156

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Data Brief. 2018 Aug 31:20:1105-1114. doi: 10.1016/j.dib.2018.08.156. eCollection 2018 Oct.

Authors

Indrajit Bandyopadhyay¹, Sandipan Roy Chowdhury¹, Nishant P Visavadiya¹, Sidney M Hecht¹, Omar M Khdour¹

Affiliation

¹ Biodesign Center for BioEnergetics, and School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.

Abstract

As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.