5'-(CGA) n sequence-assisted pH-controlled assembly of supramolecular DNA nanostructure

Yuting Yan; Yanwei Cao; Chunsheng Xiao; Yang Li; Xiaoxuan Xiang; Xinhua Guo

doi:10.1098/rsos.180123

5'-(CGA) _n sequence-assisted pH-controlled assembly of supramolecular DNA nanostructure

R Soc Open Sci. 2018 Aug 1;5(8):180123. doi: 10.1098/rsos.180123. eCollection 2018 Aug.

Authors

Yuting Yan¹, Yanwei Cao¹, Chunsheng Xiao², Yang Li¹, Xiaoxuan Xiang¹, Xinhua Guo^{1

3}

Affiliations

¹ State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China.
² Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
³ Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University, Changchun 130012, People's Republic of China.

Abstract

Herein, the DNA strands containing 5'-(CGA) _n and consecutive guanines are used to construct supramolecular DNA nanostructures that are size-controlled by pH values. Additionally, the introduction of thymine linkers within DNA nanostructures is necessary to maintain the stability of long-sized nanostructures. This work also demonstrates a method for accurately building DNA nanostructures.

Keywords: CGA DNA sequence; DNA assembly; mass spectrometry; pH-controlled DNA nanostructure.

Associated data

figshare/10.6084/m9.figshare.c.4173194
Dryad/10.5061/dryad.55t3fb5