Spermatic mitochondria: role in oxidative homeostasis, sperm function and possible tools for their assessment

Zygote. 2018 Aug;26(4):251-260. doi: 10.1017/S0967199418000242. Epub 2018 Sep 18.

Abstract

SummaryDespite sperm mitochondrial relevance to the fertilization capacity, the processes involved in the production of ATP and functional dynamics of sperm mitochondria are not fully understood. One of these processes is the paradox involved between function and formation of reactive oxygen species performed by the organelle. Therefore, this review aimed to provide data on the role of sperm mitochondria in oxidative homeostasis and functionality as well the tools to assess sperm mitochondrial function.

Keywords: Glycolysis; Mitochondrion; Oxidative phosphorylation; Reactive Oxygen Species; Sperm.

Publication types

  • Review

MeSH terms

  • Animals
  • Homeostasis
  • Humans
  • Male
  • Mitochondria / physiology*
  • Oxidative Stress*
  • Reactive Oxygen Species
  • Sperm Motility*
  • Spermatozoa / physiology*

Substances

  • Reactive Oxygen Species