Teodoro, CL, Gáspari, AF, Berton, R, Barbieri, JF, Silva, M, Castaño, LAA, Guimarães, P, and Moraes, AC. Familiarization with airflow-restriction mask during resistance exercise: Effect on tolerance and total volume. J Strength Cond Res 33(7): 1762-1765, 2019-This study investigated whether familiarization with the airflow-restriction mask (AIRfr) increases tolerance and avoids negative effects on performance of resistance exercise (RE). Ten resistance-trained male subjects performed a familiarization session (FAM), followed by 2 testing sessions, with the AIRfr and without airflow restriction (SHAM) in a counterbalanced and randomized cross-over design. The FAM was performed with the same number of sets, load, and level of airflow-restriction as the AIRfr experimental session. Each session consisted of 4 sets of the leg press exercise with 70% 1 repetition maximum until voluntary failure and a 90-second rest interval between sets. During the FAM, 4 of the 10 subjects expressed some intolerance to the use of airflow restriction. Total volume was lower in the FAM than in the AIRfr (p = 0.01) and the SHAM (p = 0.02), whereas no differences were observed between the AIRfr and the SHAM (p = 0.90). The first use of the AIRfr may not be well tolerated by all subjects. However, a familiarization session with the AIRfr avoids negative interferences in the total volume during RE.