Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies

Paris C Papagianis; J J Pillow; Timothy J Moss

doi:10.1016/j.prrv.2018.07.007

Bronchopulmonary dysplasia: Pathophysiology and potential anti-inflammatory therapies

Paediatr Respir Rev. 2019 Apr:30:34-41. doi: 10.1016/j.prrv.2018.07.007. Epub 2018 Jul 29.

Authors

Paris C Papagianis¹, J J Pillow², Timothy J Moss³

Affiliations

¹ The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynecology, Monash University, Clayton, VIC 3168, Australia; Human Sciences and Centre for Neonatal Research and Education, The University of Western Australia, Crawley, WA, Australia. Electronic address: paris.papagianis@monash.edu.
² Human Sciences and Centre for Neonatal Research and Education, The University of Western Australia, Crawley, WA, Australia. Electronic address: jane.pillow@uwa.edu.au.
³ The Ritchie Centre, Hudson Institute of Medical Research, Department of Obstetrics and Gynecology, Monash University, Clayton, VIC 3168, Australia. Electronic address: tim.moss@monash.edu.

PMID: 30201135
DOI: 10.1016/j.prrv.2018.07.007

Abstract

Inflammation of the preterm lungs is key to the pathogenesis of bronchopulmonary dysplasia (BPD), whether it arises as a consequence of intrauterine inflammation or postnatal respiratory management. This review explores steroidal and non-steroidal therapies for reducing neonatal pulmonary inflammation, aimed at treating or preventing BPD.

Keywords: Bronchopulmonary dysplasia; Chorioamnionitis; Dexamethasone; Glucocorticoid; Inflammation; Pulmonary.

Publication types

Review

MeSH terms

Anti-Inflammatory Agents / therapeutic use*
Bronchopulmonary Dysplasia / drug therapy*
Bronchopulmonary Dysplasia / immunology*
Bronchopulmonary Dysplasia / physiopathology
Chorioamnionitis / immunology
Dexamethasone / therapeutic use
Female
Fetal Organ Maturity
Glucocorticoids / therapeutic use*
Humans
Infant, Extremely Premature
Infant, Newborn
Infant, Premature
Inflammation
Interleukin 1 Receptor Antagonist Protein / therapeutic use
NLR Family, Pyrin Domain-Containing 3 Protein / antagonists & inhibitors
Neonatal Sepsis / immunology
Pentoxifylline / therapeutic use
Pregnancy
Prenatal Care

Substances

Anti-Inflammatory Agents
Glucocorticoids
Interleukin 1 Receptor Antagonist Protein
NLR Family, Pyrin Domain-Containing 3 Protein
Dexamethasone
Pentoxifylline