Detection and Treatment of Primary Prostatic Melanoma

Abstract

Objective: To describe a case of primary melanoma of the prostate gland, then review the published literature of similar cases.

Methods: Presentation of the clinical course of a 42-year-old man diagnosed with primary melanoma of the prostate after presenting with gross hematuria. Review of published literature.

Results: Primary melanoma of the genitourinary tract is a very rare disease, representing less than 1% of all melanomas in men. Only 6 cases of primary melanomas have been previously reported in the English literature.

Conclusion: The current report emphasizes the importance of a multidisciplinary approach and adherence to treatment principles in cutaneous melanoma. With complete surgical extirpation (including extended pelvic lymphadenectomy as needed), close surveillance using 18F-FDG PET/CT, and aggressive systemic treatment in patients with good performance status, cure can be achieved.