CAP-Inhibition, Molecular Diagnostics, and Total IgE in the Evaluation of Polistes and Vespula Double Sensitization

Int Arch Allergy Immunol. 2018;177(4):365-369. doi: 10.1159/000491939. Epub 2018 Sep 3.

Abstract

Cross-reactions between Polistes dominula and Vespula species are common in southern Europe. Currently, only CAP-inhibition demonstrates high accuracy in identifying genuine sensitizations, but this method is time-consuming and expensive, so a new approach is required. This study investigates skin tests, molecular diagnostics, total IgE (tIgE), and the Ves v 5/Pol d 5 (or vice versa) ratio. The ratio generated low-accuracy results and poor agreement with CAP-inhibition, and we did not find any agreement between CAP-inhibition test and double values of Ves v 5/Pol d 5. Nevertheless, a slight diagnostic improvement was obtained when Ves v 5/tIgE and Pol d 5/tIgE were measured.

Keywords: Allergy; CAP-inhibition; Cross-reactivity; Polistes; Vespula.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Allergens / immunology*
  • Anaphylaxis / diagnosis*
  • Animals
  • Child
  • Cross Reactions*
  • Desensitization, Immunologic / methods*
  • Europe
  • Female
  • Humans
  • Hypersensitivity / diagnosis*
  • Immunization
  • Immunoglobulin E / blood
  • Insect Bites and Stings / diagnosis*
  • Male
  • Middle Aged
  • Pathology, Molecular
  • Reproducibility of Results
  • Skin Tests
  • Venoms / immunology
  • Wasps / immunology
  • Young Adult

Substances

  • Allergens
  • Venoms
  • Ves v 5 allergen
  • Immunoglobulin E