Abstract
Background:
Cerebral cavernous malformations (CCMs) are vascular malformations that account for 5%-15% of all central nervous system vascular malformations. However, multiple CCMs, which can be sporadic or familial, are rare, with a prevalence of 0.1%-0.5%.
Case description:
Here, we presented a rare case of sporadic multiple CCMs in an infant, which were accompanied with multiple cavernous malformations of the chest and skin.
Conclusions:
CCMs were pathologically diagnosed through the total resection of the pineal regional lesion. We also observed a spontaneous regression of the remaining lesions during a follow-up period of 2 years. To our knowledge, this is the first case of CCMs in an infant in the English-language literature.
Keywords:
Cerebral cavernous malformations; Infant; Multiple; Regression.
Copyright © 2018 Guangzhou Women and Children's Medical Center. Published by Elsevier Inc. All rights reserved.
MeSH terms
-
Brain Neoplasms / diagnosis*
-
Brain Neoplasms / genetics
-
Brain Neoplasms / surgery
-
Cerebrospinal Fluid Shunts
-
Female
-
Hemangioma, Cavernous, Central Nervous System / diagnosis*
-
Hemangioma, Cavernous, Central Nervous System / genetics
-
Hemangioma, Cavernous, Central Nervous System / surgery
-
Humans
-
Hydrocephalus / diagnosis
-
Hydrocephalus / genetics
-
Hydrocephalus / surgery
-
Infant
-
Infant, Newborn
-
Magnetic Resonance Imaging
-
Male
-
Neoplasm Regression, Spontaneous
-
Neoplasms, Multiple Primary / diagnosis*
-
Neoplasms, Multiple Primary / genetics
-
Neoplasms, Multiple Primary / surgery
-
Pinealoma / diagnosis
-
Pinealoma / genetics
-
Pinealoma / surgery
-
Platelet Endothelial Cell Adhesion Molecule-1 / genetics
-
Pregnancy
-
Skin Neoplasms / diagnosis*
-
Skin Neoplasms / genetics
-
Skin Neoplasms / surgery
-
Thoracic Neoplasms / diagnosis*
-
Thoracic Neoplasms / genetics
-
Tomography, X-Ray Computed
-
Ultrasonography, Prenatal
Substances
-
Platelet Endothelial Cell Adhesion Molecule-1