Practice pattern changes and improvements in hematopoietic cell transplantation for primary immunodeficiencies

Rebecca A Marsh; Kyle M Hebert; Daniel Keesler; Jaap J Boelens; Christopher C Dvorak; Michael J Eckrich; Neena Kapoor; Suhag Parikh; Mary Eapen

doi:10.1016/j.jaci.2018.08.010

Practice pattern changes and improvements in hematopoietic cell transplantation for primary immunodeficiencies

J Allergy Clin Immunol. 2018 Dec;142(6):2004-2007. doi: 10.1016/j.jaci.2018.08.010. Epub 2018 Aug 28.

Authors

Rebecca A Marsh¹, Kyle M Hebert², Daniel Keesler², Jaap J Boelens³, Christopher C Dvorak⁴, Michael J Eckrich⁵, Neena Kapoor⁶, Suhag Parikh⁷, Mary Eapen²

Affiliations

¹ Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital, Cincinnati, Ohio. Electronic address: Rebecca.Marsh@cchmc.org.
² Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wis.
³ SCT and Cellular Therapy Program, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY.
⁴ Division of Pediatric Allergy, Immunology & Bone Marrow Transplantation, Benioff Children's Hospital, University of California San Francisco, San Francisco, Calif.
⁵ Pediatric Blood and Marrow Stem Cell Transplantation Program, Texas Transplant Institute, San Antonio, Tex.
⁶ Blood and Marrow Transplant Laboratory, Children's Hospital of Los Angeles, Los Angeles, Calif.
⁷ Divison of Pediatric Blood and Marrow Transplantation, Duke University Medical Center, Durham, NC.

Abstract

Allogeneic HCT practice patterns for PID changed between 1974–2016. Three-year survival improved to >70% for SCID and non-SCID patients after 1999, and further increased to 94% for SCID patients transplanted 2010–2016 following newborn screening diagnosis.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Child
Child, Preschool
Hematopoietic Stem Cell Transplantation*
Humans
Immunologic Deficiency Syndromes / therapy*
Infant
Practice Patterns, Physicians'*
Survival Analysis

Abstract

Publication types

MeSH terms

Grants and funding