Salzmann's nodular degeneration of cornea associated with thyroid eye disease

Orbit. 2019 Aug;38(4):325-327. doi: 10.1080/01676830.2018.1505921. Epub 2018 Aug 27.

Abstract

Salzmann's nodular degeneration (SND) typically occurs in patients who are female, 50-60 years old, and have a history of corneal inflammation and irritation. Multiple case reports have documented associations between SND and trachoma, viral infections, trauma, contact lens wear, corneal surgeries and corneal exposure. The authors describe a patient with bilateral SND confirmed by anterior segment optical coherence tomography (OCT) imaging in the context of thyroid eye disease (TED) and history of LASIK. Treatment involved propylthiouracil (PTU), artificial tear use, loteprednol etabonate ophthalmic gel, eyelid taping and selenium supplementation and prospective superficial keratectomy with diamond burr polish.

Keywords: Graves disease; LASIK; Salzmann’s nodular degeneration; thyroid eye disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Corneal Dystrophies, Hereditary / diagnostic imaging
  • Corneal Dystrophies, Hereditary / etiology*
  • Corneal Dystrophies, Hereditary / physiopathology
  • Corneal Topography
  • Female
  • Graves Ophthalmopathy / complications*
  • Graves Ophthalmopathy / diagnosis
  • Humans
  • Limbus Corneae / diagnostic imaging
  • Limbus Corneae / pathology*
  • Prospective Studies
  • Slit Lamp
  • Tomography, Optical Coherence
  • Vision Disorders / diagnosis
  • Vision Disorders / etiology
  • Vision Disorders / physiopathology
  • Visual Acuity / physiology