Purpose: To evaluate ultrasound biomicroscopy (UBM) characteristics of trabeculodysgenesis and explore its correlation with the outcomes of microcatheter-assisted trabeculotomy (MAT) in eyes with primary congenital glaucoma (PCG).
Design: A prospective, interventional case series.
Methods: Patients with newly diagnosed PCG were consecutively recruited, and subsequently MAT was tried as their first glaucoma surgery. All participants underwent UBM prior to surgery. The trabeculodysgenesis was classified into 3 types according to the severity of the anterior insertion of iris and ciliary processes (type 1, severe trabeculodysgenesis; type 2, moderate trabeculodysgenesis; type 3, mild trabeculodysgenesis). Surgical success was defined as a postoperative intraocular pressure of ≤ 21 mm Hg with at least a 30% reduction from preoperative intraocular pressure without additional medical or surgical therapy, and with decreased corneal edema, stabilized corneal diameter, and no additional optic nerve damage for at least 6 months after surgery.
Results: MAT was tried on 49 eyes with PCG (33 patients) as the first glaucoma surgery. The ratios of the type of trabeculodysgenesis (type 1: type 2: type 3) were 1:1:1.7 among eyes. In multivariate analysis, age (at the time of operation) (P < .001) and sex (P = .002) were factors associated with the type of trabeculodysgenesis. At 24-month follow-up, type 1 achieved a 57.1% surgical success rate, type 2 achieved 70.5%, and type 3 achieved 95.5% (P = .022). Severe trabeculodysgenesis (P = .014), as well as poorer corneal transparency (P = .037), was associated with worse surgical outcome.
Conclusions: UBM grading of trabeculodysgenesis in PCG is helpful for MAT prognosis. Combined with preoperative corneal opacity score, it may be used to predict the outcome of MAT surgery.
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