Copper(I)-Catalyzed Oxydifluoroalkylation of Alkenes: A Route to Functionalization of Lactones

Org Lett. 2018 Sep 7;20(17):5149-5152. doi: 10.1021/acs.orglett.8b02069. Epub 2018 Aug 24.

Abstract

An efficient copper(I)-catalyzed oxydifluoroalkylation of unsaturated carboxylic acids has been developed under mild reaction conditions. Various α-bromodifluoromethyl substituted heterocycles, esters, amides, and ketones were successfully employed as the CF2 source. This cost-effective copper(I) catalysis provides expedient access to high valued lactones with ample substrate scope, wide functional group tolerance, and up to 98% yield.

Publication types

  • Research Support, Non-U.S. Gov't