Tandem Duplications May Supply the Missing Genetic Alterations in Many Triple-Negative Breast and Gynecological Cancers

Manisha Rao; Scott Powers

doi:10.1016/j.ccell.2018.07.011

Tandem Duplications May Supply the Missing Genetic Alterations in Many Triple-Negative Breast and Gynecological Cancers

Cancer Cell. 2018 Aug 13;34(2):179-180. doi: 10.1016/j.ccell.2018.07.011.

Authors

Manisha Rao¹, Scott Powers²

Affiliations

¹ Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA.
² Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: scott.powers@stonybrook.edu.

PMID: 30107171
DOI: 10.1016/j.ccell.2018.07.011

Abstract

In this issue of Cancer Cell, Menghi et al. show that tandem duplications (TDs) are a common genetic feature of gynecological and triple-negative breast cancers. They also provide evidence that these TDs generate genetic alterations driving these cancers, which, if substantiated, will fundamentally change our understanding of their oncogenesis.

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MeSH terms

Breast Neoplasms / genetics*
Genome
Humans
Mutation
Phenotype
Triple Negative Breast Neoplasms / genetics*