One of the most important objectives nowadays in the field of chemical modification of carbon nanotubes (CNTs) is to control the degree of functionalization, since excessive modification can disrupt the π-conjugated system and adversely affect their useful properties. Covalent functionalization is one of the most common methods for the modification of single-walled carbon nanotubes (SWCNTs). However, only a few examples have appeared in the last few years regarding the control of the functionalization degree and the reversibility of the reaction. We present here an approach for the retro-functionalization of SWCNTs which could be applied to different types of covalent functionalizations, allowing the restoration of the π-conjugated structure. The process is performed through the combination of ionic liquids plus microwave irradiation and it is applicable to the retro-arylation and retro-cycloaddition reactions on SWCNTs. The successful retro-functionalization is monitored by Raman spectroscopy, thermogravimetric analysis and UV-Vis-NIR spectroscopy.