Resident Breast T Cells: The Troops Are Already There

Aislyn Schalck; Chantale Bernatchez; Nicholas Navin

doi:10.1016/j.molmed.2018.07.006

Resident Breast T Cells: The Troops Are Already There

Trends Mol Med. 2018 Oct;24(10):821-822. doi: 10.1016/j.molmed.2018.07.006. Epub 2018 Aug 1.

Authors

Aislyn Schalck¹, Chantale Bernatchez², Nicholas Navin³

Affiliations

¹ Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
² Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³ Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: nnavin@mdanderson.org.

Abstract

The role of tissue-resident memory T (T_RM) cells in breast cancer progression has been difficult to study. Savas et al. [1] (Nat. Med. 2018;24:986-993) used single-cell RNA sequencing to identify T_RM cells in triple-negative breast cancer patients and demonstrated their prognostic value for predicting survival.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Breast Neoplasms*
CD8-Positive T-Lymphocytes
Disease Progression
Humans
Immunologic Memory*
Prognosis

Grants and funding

P30 CA016672/CA/NCI NIH HHS/United States