Acute lung injury (ALI) is a clinically common critical disease with various treatment methods. Stem cell has drawn great attention for excellent performance in treatment of ALI. However, due to its high apoptosis rate, the further clinical application of stem cell is restricted. Exosomes are a kind of extracellular vesicles secreted by cells, which play important role in injury repair with further research about exosomes. This article reviews current situation, brief introduction to exosomes, repair effects of exosomes on ALI, and the potential signal pathway.
急性肺损伤是临床常见的危重疾病，治疗方法较多。干细胞在急性肺损伤治疗方面具有良好的效果，因而备受关注。但干细胞凋亡率高，限制了其进一步的临床应用。外泌体是细胞分泌的一种胞外囊泡，随着对外泌体研究的不断深入，其在治疗损伤修复中的优势逐步显现。本文从急性肺损伤的研究现状，外泌体的简介，其对急性肺损伤的修复作用及可能的信号通路等方面予以综述。.
Keywords: Acute lung injury; Exosomes; Stem cells.