Lack of central and peripheral nervous system synuclein pathology in R1441G LRRK2-associated Parkinson's disease

Dolores Vilas; Ellen Gelpi; Iban Aldecoa; Oriol Grau; Roberta Rodriguez-Diehl; Serge Jaumà; María José Martí; Eduard Tolosa

doi:10.1136/jnnp-2018-318473

Lack of central and peripheral nervous system synuclein pathology in R1441G LRRK2-associated Parkinson's disease

J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):832-833. doi: 10.1136/jnnp-2018-318473. Epub 2018 Jul 27.

Authors

Dolores Vilas^{1

2}, Ellen Gelpi^{3

4}, Iban Aldecoa^{3

5}, Oriol Grau⁶, Roberta Rodriguez-Diehl^{3

7}, Serge Jaumà⁸, María José Martí^{1

9

10}, Eduard Tolosa^{11

9

10}

Affiliations

¹ Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Barcelona, Spain.
² Movement Disorders Unit, Neurology Service, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.
³ Neurological Tissue Bank of the Biobank-Hospital Clinic-IDIBAPS, Barcelona, Spain.
⁴ Institute of Neurology, Medical University of Vienna, Vienna, Austria.
⁵ Pathology Department, Biomedical Diagnostic Center, Hospital Clinic de Barcelona, Barcelona, Spain.
⁶ Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Barcelona, Spain.
⁷ Behavioral and Cognitive Neurology Unit, Department of Neurology and LIM 22, University of São Paulo, São Paulo, Brazil.
⁸ Neurology Service, Hospital Universitari de Bellvitge, Barcelona, Spain.
⁹ Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
¹⁰ Centre for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
¹¹ Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Barcelona, Spain ETOLOSA@clinic.cat.

PMID: 30054313
DOI: 10.1136/jnnp-2018-318473

No abstract available

Keywords: Parkinson's disease; genetics; movement disorders.

Publication types

Case Reports
Letter

MeSH terms

Aged
Brain / pathology*
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / genetics*
Male
Mutation
Parkinson Disease / genetics
Parkinson Disease / pathology*
Peripheral Nervous System / pathology*
alpha-Synuclein / metabolism*

Substances

alpha-Synuclein
LRRK2 protein, human
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2