MitraClip in Patients With Mitral Regurgitation and Left Ventricular Ejection Fraction <30% - Potential Implications for the Treatment of Patients in Japan

Circ J. 2018 Sep 25;82(10):2672-2675. doi: 10.1253/circj.CJ-18-0536. Epub 2018 Jul 25.

Abstract

Background: The effect of the unique Japanese indication for MitraClip based on left ventricular ejection fraction (LVEF) is unclear.

Methods and results: We analyzed 874 patients who underwent MitraClip because of mitral regurgitation (MR) and compared the characteristics and outcomes between patients with LVEF <30% and ≥30%. Patients with LVEF ≤30% accounted for 33% of the study population and had a higher prevalence of functional MR. Severity of MR after MitraClip was comparable, and LVEF <30% did not independently affect survival.

Conclusions: Japanese unique indication based on LVEF may exclude one third of patients who were treated with MitraClip in Europe.

Keywords: Left ventricular ejection fraction; MitraClip; Mitral regurgitation.

MeSH terms

  • Aged
  • Female
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Mitral Valve / surgery
  • Mitral Valve Insufficiency / therapy*
  • Stroke Volume*
  • Survival Rate
  • Treatment Outcome