The transmission dynamic of different hepatitis B-infected individuals with the effect of hospitalization

J Biol Dyn. 2018 Dec;12(1):611-631. doi: 10.1080/17513758.2018.1500649.

Abstract

We propose an epidemic model for the transmission of hepatitis B virus along with the classification of different infection phases and hospitalized class. We formulate the model and discuss its basic mathematical properties, e.g. existence, positivity, and biological feasibility. Exploiting the next generation matrix approach, we find the basic reproductive number of the model. We perform sensitivity analysis to illustrate the effect of various parameters on the transmission of the disease. We investigate stability of the equilibria of the model in terms of the basic reproduction number. Conditions for the stability of the proposed model are obtained using various approaches. Finally, we perform the numerical simulations to discuss sensitivity analysis and to support our analytical work.

Keywords: Mathematical modelling; basic reproduction number; different phases of hepatitis B; hospitalization; numerical simulation; sensitivity analysis; stability analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basic Reproduction Number
  • Computer Simulation
  • Hepatitis B / transmission*
  • Hospitalization*
  • Humans
  • Models, Biological
  • Numerical Analysis, Computer-Assisted
  • Vaccination