Direct Assembly of 4-Substituted Quinolines with Vinyl Azides as a Dual Synthon via C═C and C-N Bond Cleavage

Org Lett. 2018 Aug 3;20(15):4434-4438. doi: 10.1021/acs.orglett.8b01718. Epub 2018 Jul 20.

Abstract

An unprecedented Zn-promoted selective cleavage of vinyl azides for the synthesis of 4-substituted quinolines is developed. In this conversion, vinyl azides function as a dual synthon via C═C and C-N bond cleavage with two C═C bonds and one C═N bond formation in a one-step manner. The reaction is appreciated for its readily accessible substrates, high step economy, mild conditions, and use of air as the sole oxidant.

Publication types

  • Research Support, Non-U.S. Gov't