Abstract
A unique chemically induced proximity method is engineered based on mutant antibody VL domain using a fluorogenic malachite green derivative as the inducer, which gives fluorescent signals upon VL domain dimerization while simultaneously inducing downstream biological effects.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Dimerization
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Fluorescence
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Fluorescent Dyes / chemistry*
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HEK293 Cells
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Humans
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Protein Domains
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Proteins / chemistry*
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Rosaniline Dyes / chemistry*
Substances
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Fluorescent Dyes
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Proteins
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Rosaniline Dyes
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malachite green