Double-Strand DNA Sensing Aim2 Inflammasome Regulates Atherosclerotic Plaque Vulnerability

Circulation. 2018 Jul 17;138(3):321-323. doi: 10.1161/CIRCULATIONAHA.117.033098.

Authors

Nicole Paulin^{1

2

3}, Joana R Viola^{1

2}, Sanne L Maas¹, Renske de Jong¹, Teresa Fernandes-Alnemri⁴, Christian Weber^{1

2}, Maik Drechsler^{1

2}, Yvonne Döring^{1

2}, Oliver Soehnlein^{5

2

6}

Affiliations

¹ Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany (N.P., J.R.V., S.L.M., R.d.J., C.W., M.D., Y.D., O.S.).
² DZHK, partner site Munich Heart Alliance, Germany (N.P., J.R.V., C.W., M.D., Y.D., O.S.).
³ Centre for Preclinical Research, Klinikum Rechts der Isar, Munich, Germany (N.P.).
⁴ Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA (T.F.-A.).
⁵ Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany (N.P., J.R.V., S.L.M., R.d.J., C.W., M.D., Y.D., O.S.). oliver.soehnlein@gmail.com.
⁶ Department of Physiology and Pharmacology (FyFa), Karolinska Institutet, Stockholm, Sweden (O.S.).

PMID: 30012706
DOI: 10.1161/CIRCULATIONAHA.117.033098

No abstract available

Keywords: atherosclerosis; cytokines; inflammasomes; inflammation; interleukins.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Atherosclerosis / genetics
Atherosclerosis / metabolism*
DNA / genetics*
DNA-Binding Proteins / antagonists & inhibitors
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Disease Models, Animal
Humans
Inflammasomes / metabolism*
Mice
Mice, Knockout, ApoE
Plaque, Atherosclerotic / genetics
Plaque, Atherosclerotic / metabolism*
RNA, Small Interfering / genetics

Substances

AIM2 protein, human
DNA-Binding Proteins
Inflammasomes
RNA, Small Interfering
DNA