N1-methyladenosine methylome in messenger RNA and non-coding RNA

Curr Opin Chem Biol. 2018 Aug:45:179-186. doi: 10.1016/j.cbpa.2018.06.017. Epub 2018 Jul 9.

Abstract

Chemical modifications to rRNA, tRNA and mRNA provide a new regulatory layer of gene expression, which is termed as the `epitranscriptome'. N1-methyladenosine (m1A), first characterized more than 50 years ago, is a well-known modification in rRNA and tRNA. m1A in these abundant non-coding RNAs plays important roles in maintaining their biological functions. Recent studies also reveal that m1A is present in both nuclear-encoded and mitochondrial-encoded mRNA and is dynamically regulated by environmental and developmental conditions; m1A is found in a subset of nuclear-encoded long non-coding RNAs as well. Finally, we also discuss the potential challenges of identifying m1A modification in the human transcriptome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / analysis
  • Adenosine / genetics
  • Animals
  • Epigenesis, Genetic*
  • Humans
  • Methylation
  • RNA, Long Noncoding / chemistry
  • RNA, Long Noncoding / genetics*
  • RNA, Messenger / chemistry
  • RNA, Messenger / genetics*
  • RNA, Mitochondrial / chemistry
  • RNA, Mitochondrial / genetics*
  • RNA, Nuclear / chemistry
  • RNA, Nuclear / genetics*
  • Transcriptome*

Substances

  • RNA, Long Noncoding
  • RNA, Messenger
  • RNA, Mitochondrial
  • RNA, Nuclear
  • mitochondrial messenger RNA
  • 1-methyladenosine
  • Adenosine