N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist

J Med Chem. 1985 Dec;28(12):1756-9. doi: 10.1021/jm00150a002.
No abstract available

MeSH terms

  • Animals
  • Binding, Competitive
  • Cattle
  • Cerebral Cortex / metabolism
  • Chemical Phenomena
  • Chemistry
  • Clonidine / pharmacology
  • Male
  • Prazosin / metabolism
  • Pupil / drug effects
  • Quinolizines / chemical synthesis
  • Quinolizines / metabolism
  • Quinolizines / pharmacology*
  • Rats
  • Receptors, Adrenergic, alpha / metabolism*
  • Stereoisomerism
  • Structure-Activity Relationship
  • Yohimbine / metabolism

Substances

  • Quinolizines
  • Receptors, Adrenergic, alpha
  • Yohimbine
  • N-(1,3,4,6,7,12b-hexahydro-2H-benzo(b)furo(2,3-a)quinolizin-2-yl)-N-methyl-2-hydroxyethanesulfonamide
  • Clonidine
  • Prazosin