Immunoglobulin heavy chain variable region gene and prediction of time to first treatment in patients with chronic lymphocytic leukemia: Mutational load or mutational status? Analysis of 1003 cases

Affiliations

• ¹ Biotechnology Research Unit, Azienda Sanitaria Provinciale di Cosenza, Aprigliano (CS), Italy.
• ² Department of Medicine, Division of Hematology, Stanford University, California.
• ³ Hematology Unit, Department of Onco-hematology, A.O. of Cosenza, Cosenza, Italy.
• ⁴ Hematology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
• ⁵ Hematology, Department of Cellular Biotechnologies and Hematology, 'Sapienza' University, Rome, Italy.
• ⁶ Oncology Institute of Southern Switzerland and Institute of Oncology Research, Bellinzona, Switzerland.
• ⁷ Unità di Ematologia, Ospedale Vito Fazzi, Lecce, Italy.
• ⁸ Department of Oncology and Haematology, Pugliese-Ciaccio Hospital, Catanzaro, Italy.
• ⁹ Department of Hematology, Ospedale Santo Spirito, Pescara, Italy.
• ¹⁰ Division of Hematology, AOU Policlinico-OVE, University of Catania, Catania, Italy.
• ¹¹ UO Molecular Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
• ¹² Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
• ¹³ Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota.
• ¹⁴ Consiglio Nazionale delle Ricerche, Istituto di Biomedicina ed Immunologia Molecolare, Reggio Calabria, Italy.
• ¹⁵ Division of Haematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.
• ¹⁶ Department of Experimental Medicine, University of Genova, Genoa, Italy.