Cross-reactivity pattern of a rare presentation of generalized delayed-type hypersensitivity to local anaesthetics

Asian Pac J Allergy Immunol. 2019 Sep;37(3):179-182. doi: 10.12932/AP-040218-0251.

Abstract

A seven-year-old girl developed angioedema and a generalized, erythematous rash several hours after receiving lignocaine with adrenaline reproducible on provocative challenge, confirming the first known case of generalized delayed-type hypersensitivity to local anaesthetics with cross-reactivity to bupivacaine but not chloroprocaine.

Publication types

  • Case Reports

MeSH terms

  • Allergens / immunology
  • Anesthetics, Local / adverse effects*
  • Child
  • Cross Reactions / immunology*
  • Drug Hypersensitivity / diagnosis*
  • Drug Hypersensitivity / immunology*
  • Female
  • Humans
  • Hypersensitivity, Delayed / diagnosis*
  • Hypersensitivity, Delayed / immunology*
  • Skin / pathology

Substances

  • Allergens
  • Anesthetics, Local