Glutathione-responsive homodithiacalix[4]arene-based nanoparticles for selective intracellular drug delivery

Chem Commun (Camb). 2018 Jul 17;54(58):8128-8131. doi: 10.1039/c8cc05031g.

Abstract

Glutathione-responsive, paclitaxel-loaded nanoparticles based on homodithiacalix[4]arene were successfully developed, exhibiting selective drug release in cancer cells.

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / pharmacology*
  • Calixarenes / chemistry
  • Calixarenes / metabolism*
  • Carbocyanines / metabolism
  • Disulfides / chemistry
  • Disulfides / metabolism
  • Drug Carriers / chemistry
  • Drug Carriers / metabolism*
  • Drug Liberation
  • Glutathione / chemistry*
  • Humans
  • MCF-7 Cells
  • Mice
  • Nanoparticles / chemistry
  • Nanoparticles / metabolism*
  • Oxidation-Reduction
  • Paclitaxel / administration & dosage
  • Paclitaxel / pharmacology*
  • Particle Size
  • RAW 264.7 Cells

Substances

  • Antineoplastic Agents
  • Carbocyanines
  • Disulfides
  • Drug Carriers
  • cyanine dye 5
  • Calixarenes
  • Glutathione
  • Paclitaxel