Oral cancer is the fifth most common cancer in the world, accounting for numerous deaths annually. The 5-year survival rate remains approximately 50% for oral squamous cell carcinoma (OSCC) in the past several decades. Early detection plays a vital role in the survival rate of the patients. There is no accurate, cost-effective, and reliable method for the screening of patients with OSCC. Hence, many patients are diagnosed at advanced stages. Early detection would, therefore, help to identify patients and modify treatment with close monitoring. Lab on a Chip or micro-total-analysis systems are one of the microfluidics technologies that are defined as adaptation, miniaturization, integration, and automation of analytical laboratory procedures into a single device or "chip." This technology assures the replacement of complicated techniques with miniaturized, integrated, programmed, and economical diagnostic devices. Hence, this system provides a means for rapid, automated, molecular analysis of cancer cells.
Keywords: Diagnostic aids; lab on a chip; microfluidics; oral cancer; oral squamous cell carcinoma.