Abstract
A novel isoquinoline alkaloid, mahimbrine A, possessing a rare benzotropolone framing scaffold, was isolated from the endemic plant of Mahonia imbricata. Its structure was established on the basis of extensive spectroscopic analysis. A plausible biosynthetic route of mahimbrine A was proposed. Mahimbrine A showed no antimicrobial activity at the concentration of 1 mg/mL.
Keywords:
Berberidaceae; Mahonia imbricata; isoquinoline alkaloid; mahimbrine A.
MeSH terms
-
Alkaloids / chemical synthesis
-
Alkaloids / chemistry*
-
Alkaloids / pharmacology
-
Anti-Infective Agents / pharmacology
-
Biflavonoids / chemistry*
-
Carbon-13 Magnetic Resonance Spectroscopy
-
Catechin / analogs & derivatives*
-
Catechin / chemistry
-
Isoquinolines / chemical synthesis
-
Isoquinolines / chemistry*
-
Isoquinolines / pharmacology
-
Mahonia / chemistry*
-
Microbial Sensitivity Tests
-
Proton Magnetic Resonance Spectroscopy
Substances
-
Alkaloids
-
Anti-Infective Agents
-
Biflavonoids
-
Isoquinolines
-
benzotropolone
-
mahimbrine A
-
Catechin
-
isoquinoline