Molecular fluorescence-guided surgery of peritoneal carcinomatosis of colorectal origin: A narrative review

J Surg Oncol. 2018 Aug;118(2):332-343. doi: 10.1002/jso.25106. Epub 2018 Jun 24.

Abstract

Patients with peritoneal carcinomatosis (PC) from colorectal origin may undergo cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) as a curative approach. One major prognostic factor that affects survival is completeness of cytoreduction. Molecular Fluorescence Guided Surgery (MFGS) is a novel intraoperative imaging technique that may improve tumor identification in the future, potentially preventing over- and under-treatment in these patients. This narrative review outlines a chronological overview of MFGS development in patients with PC of colorectal origin.

Keywords: colorectal cancer; molecular fluorescence-guided surgery; peritoneal carcinomatosis; review.

Publication types

  • Review

MeSH terms

  • Colorectal Neoplasms / diagnostic imaging
  • Colorectal Neoplasms / pathology*
  • Colorectal Neoplasms / surgery*
  • Cytoreduction Surgical Procedures / methods*
  • Humans
  • Molecular Imaging / methods*
  • Monitoring, Intraoperative / methods
  • Neoplasm Invasiveness
  • Optical Imaging / methods*
  • Peritoneal Neoplasms / diagnostic imaging
  • Peritoneal Neoplasms / pathology
  • Peritoneal Neoplasms / secondary*
  • Peritoneal Neoplasms / surgery*
  • Surgery, Computer-Assisted / methods*