External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database

Antimicrob Agents Chemother. 2018 Aug 27;62(9):e00669-18. doi: 10.1128/AAC.00669-18. Print 2018 Sep.

Abstract

Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model. Our results suggest that, with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.

Keywords: EHR; external evaluation; gentamicin; infant; pediatrics; pharmacokinetics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / therapeutic use*
  • Databases, Factual
  • Electronic Health Records
  • Female
  • Gentamicins / pharmacokinetics*
  • Gentamicins / therapeutic use*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Models, Biological

Substances

  • Anti-Bacterial Agents
  • Gentamicins