Effect of Teratogens on Development of Drosophila melanogaster

Methods Mol Biol. 2018:1797:233-241. doi: 10.1007/978-1-4939-7883-0_12.

Abstract

Prenatal exposure to various environmental teratogens such as drugs, toxins, and infectious etiologies results in a wide range of developmental abnormalities, including growth deficiency, developmental delay, structural defects, functional CNS abnormalities, and fetal death. Here, we describe the use of Drosophila melanogaster as a model organism for investigating teratogenic effects on embryonic development.

Keywords: Development; Drosophila; Embryonic cell culture; Immunostaining; Teratogen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drosophila melanogaster / drug effects
  • Drosophila melanogaster / growth & development*
  • Embryo, Nonmammalian / drug effects
  • Embryo, Nonmammalian / pathology*
  • Embryonic Development*
  • Teratogens / toxicity*
  • Toxicity Tests / methods*

Substances

  • Teratogens